By disabling nested paging (EPT), the VMM will construct page tables shadowing the ones in the guest. It is no possible for the guest to insert anything fishy into the page tables, since the VMM carefully validates each entry before shadowing it.

As a side effect of disabling nested paging, several CPU features will not be made available to the guest. Among these features are AVX, AVX2, XSAVE, AESNI, and POPCNT. Not all guests may be able to cope with dropping these features after installation. Also, for some guests, especially in SMP configurations, there could be stability issues arising from disabling nested paging. Finally, some workloads may experience a performance degradation.